PTK2 and Chagas disease: Xianxiu Wan and colleagues found that pro-inflammatory macrophages were reprogrammed to a healing phenotype by enhancing the SIRT1 activity and by inhibiting focal adhesion kinase (FAK) signaling in macrophage proliferation and activation of a pro-inflammatory reaction in Chagas disease caused by Trypanosoma cruzi (Wan et al., 2019).