SIRT1 and infection: Existing studies on the effect of SIRT1 in infection by pathogenic microorganisms and host autophagic clearance showed that Salmonella typhimurium induced SIRT1 to translocate from the nucleus to the cytoplasm and destroyed its indirect activation of AMP-activated kinase (AMPK) after infecting macrophages, thereby inhibiting autophagy in host cells (Ganesan et al., 2017).