MAPT and Cognitive impairment: A recent study showed that Tau can activate microglia through the PQBP1-CGAS-STING pathway (Jin et al., 2021), and the activated microglia can produce IL-1β, TNF-α, IL-6 and other inflammatory factors through NF-κB transcription factor, ultimately leading to cognitive impairment in mice (Wang et al., 2022).