Altered Reelin signaling is detected in human brain samples of AD patients (Notter and Knuesel, 2013; Pujadas et al., 2014), in correlation with APP/Aβ deposition (Pujadas et al., 2014) and tau phosphorylation (Hoe et al., 2009; Cuchillo-Ibáñez et al., 2013; Rice et al., 2013). This evidence concerns the gene APP and Alzheimer disease.