The presence of APP/Aβ1-42 deposits and overexpressed tau in the peripheral retina was previously reported in transgenic AD mice (Ning et al., 2008; Dutescu et al., 2009; Kocherhans et al., 2010; Latina et al., 2021a), and particularly this pathological expression was confirmed in post-mortem AD retinas (den Haan et al., 2018). Here, APP is linked to Alzheimer disease.