The mTOR pathway has been extensively implicated in neurodegenerative diseases, mainly because the overactivation of mTORC1 effectively inhibits autophagy (Menzies et al., 2015), and it has been proven that the failure of autophagy degradation is a major culprit in neurodegenerative diseases (Wong and Cuervo, 2010). The gene discussed is MTOR; the disease is neurodegenerative disease.