For instance, the variant rs636317, previously nominated by ML algorithms for variant prioritization (Corces et al., 2020), has been identified as a CTCF binding QTL that disrupts one CTCF anchor of a chromatin loop and upregulates the MS4A6A gene implicated in AD (Novikova et al., 2021b). This evidence concerns the gene CTCF and Alzheimer disease.