According to KEGG enrichment analysis, circRNAs that were dysregulated in the hippocampus of 5 × FAD mice are involved in numerous signaling pathways, several of which have been shown to be necessary for AD pathogenesis, including neurotrophin signaling pathway, axon guidance, the MAPK signaling pathway, and the FoxO signaling pathway. This evidence concerns the gene BDNF and Alzheimer disease.