ORM2 and Alzheimer disease: For this purpose, we investigated the effects of OX-A and 2-AGP on the phosphorylation of threonine 231 of Tau protein (pT231-Tau), which has been identified as a sensitive and specific early biomarker for AD diagnosis (Kiđemet-Piskač et al., 2018; Suárez-Calvet et al., 2020; Gonzalez et al., 2022).