Since pT231-Tau is a well-recognized specific early CSF marker of AD (Hampel et al., 2001; Buerger et al., 2002a,b), here we focused on the molecular pathway linking OX-A to pT231-Tau production by revealing a 2-AGP-mediated pT231-Tau phosphorylation and its detrimental effect on the hippocampal glutamatergic network underlying memory and cognitive function, in agreement with previously reported findings (Garcia-Morales et al., 2015; Roza et al., 2019). Here, ATP5MK is linked to Alzheimer disease.