Some researchers believe that the deposition and hyperphosphorylation of tau are the main pathophysiological mechanisms of PSD, studies have shown that chronic cerebral hypoperfusion may aggravate cognitive impairment in rats with acute ischemic stroke by disrupting the clearance of Aβ and tau in the glymphatic system (Back et al., 2020), this indicates that glymphatic dysfunction is a risk factor for the development of PSD. Here, MAPT is linked to Cognitive impairment.