LPO and type 2 diabetes mellitus: Montaldo et al. applied immunologically active salivary substitutes including lactoperoxidase, lysozyme, glucose oxidase, and lactoferrin with oral hygiene instructions (including the use of toothpaste, mouthwash, and moisturizing gel) to assess the participants with T2DM either having dental caries or restorations and compared to the control group (no intervention) (6).