Src could be activated by multiple signaling pathways to become phospho-Src (p-Src), and researchers had found that the expression of Src and p-Src in osteosarcoma was significantly higher, and the expression level was related to the clinical stage, tumor metastasis, and survival time of osteosarcoma, which could be used as an auxiliary index to judge the malignant phenotype of osteosarcoma and prompt the prognosis of osteosarcoma [56]. Here, SRC is linked to osteosarcoma.