For instance, the identified TFs, namely, MEF2A, FOS, STAT1, STAT3, JUND, YY1, IRF2, ARID3A, SPIB, TP53, RELA, E2F1, NFKB1, NR3C1, FOXO3, PRDM1, NRF1, and ESR1 are related to various hematological diseases. The gene discussed is SPIB; the disease is hematologic disorder.