For instance, the identified TFs, namely, MEF2A, FOS, STAT1, STAT3, JUND, YY1, IRF2, ARID3A, SPIB, TP53, RELA, E2F1, NFKB1, NR3C1, FOXO3, PRDM1, NRF1, and ESR1 are related to various hematological diseases. This evidence concerns the gene IRF2 and hematologic disorder.