Explanations for the increased incidence of particular tumors as SPMs, such as prostate cancer, may be explained by the fact that patients are susceptible to both malignancies by sharing a similar carcinogenic pathway, such as DNA repair and N-acetyltransferase 2 (NAT2) (14, 15), which could explain the link between these two cancers. This evidence concerns the gene NAT2 and Familial prostate cancer.