Post-mortem liver wedge biopsy or autopsy reports on COVID-19 death confirmed positive detection of SARS-CoV-2 RNA in nearly 70% of liver specimens, illustrating a direct infection resembling other hepatotropic viruses (e.g., hepatitis C virus) where interferon response was upregulated and JAK/STAT signaling was activated (35, 36). This evidence concerns the gene SOAT1 and infection.