The GLy482Ser (rs8192678) SNP is a variant in the protein coding sequence of PPARGC1A, whose deleterious effect has been related to obesity, as well as its associated complications, which include CHD, T2DM, non-alcoholic fatty liver disease (NAFLD), and arterial hypertension (26). The gene discussed is PPARGC1A; the disease is obesity due to melanocortin 4 receptor deficiency.