In our study, greater eGFR decline was found to be associated with having both diabetes and hypertension ( − 3.2 ± 4.3 mL/min/1.73 m2/year) as original kidney disease, to have a higher grade of albuminuria ( − 3.2 ± 2.4 mL/min/1.73 m2/year), high HbA1c (>10% was associated with an eGFR decline of − 4.1 ± 6.2 mL/min/1.73 m2/year) and not being on any medication for renin-angiotensin system block ( − 3.3 ± 3.7 mL/min/1.73 m2/year). The gene discussed is REN; the disease is Hypertension.