When checked for the pathway association of these proteins, the proteins were playing a major role in the pathways associated with cancer and signaling processes like advanced glycation end products (AGE-RAGE) signaling, Hypoxia-inducible factors (HIF-1) signaling pathway, interlukin-17 (IL-17) signaling, chemokine, and cytokine signaling, apoptosis signaling, Phosphatidylinositol 3-kinase—protein kinase B (PI3k-Akt) signaling pathway, etc (Figure 5D; Supplementary Table S6). The gene discussed is HIF1A; the disease is cancer.