Hyperlipemia is a prevalent, chronic condition that affects penile hemodynamics (25), Huang et al. found that hyperlipidemia could damage arterial endothelial cell function through cell adhesion molecule-1, cause inadequate blood supply to the penis and reduced blood flow to the Corpus cavernosum penis arteries, which could lead to erectile dysfunction and sexual dysfunction by causing of cavernosal fibrosis (26). This evidence concerns the gene CADM1 and familial hyperlipidemia.