As a ROS scavenger, it improved pancreatic β-cell function by attenuating oxidative stress through Nrf2/ARE pathway in diabetic rats (37) and ameliorated diabetic myocardial ischemia/reperfusion (MI/R) injury by reducing oxidative stress by activating the SIRT1-Nrf2 signaling pathway (65). This evidence concerns the gene SIRT1 and myocardial ischemia.