NFKB1 and breast cancer: Russo et al. (2020) analyzed the secretome of synoviocytes treated with fish-extractive CS and biofermentative BC, suggesting not only interesting similarities but also improved activity of BC in the modulation of inflammation biomarkers. BC, alone and combined with HA, was able to reduce NF-kB expression with respect to pathological human chondrocyte synoviocytes (Vassallo et al., 2021). More recently, BC was used in comparison to CS in methacrylated gelatin scaffolds, showing a role in the differentiation of stem cells into chondrocytes (Vassallo et al., 2022).