By searching for interactions across three gene sets, DEGs of AD, DEGs of IS and DTGs, eight DEGs interacting with two known drug targets were identified, which were ANXA1, SOD1, LDHB, CASP1, PRDX1, CD3D, NDUFB3, and TXN (Figure 5A). The gene discussed is PRDX1; the disease is Alzheimer disease.