CASP1 and Cerebral ischemia: Here, we identified eight DEGs, including ANXA1, SOD1, LDHB, CASP1, PRDX1, CD3D, NDUFB3, and TXN. Overwhelming evidence has confirmed the protective role of ANXA1 in neuronal apoptosis during cerebral ischemia (Zhao et al., 2015; Li et al., 2019).