Here, we identified eight DEGs, including ANXA1, SOD1, LDHB, CASP1, PRDX1, CD3D, NDUFB3, and TXN. Overwhelming evidence has confirmed the protective role of ANXA1 in neuronal apoptosis during cerebral ischemia (Zhao et al., 2015; Li et al., 2019). Here, CASP1 is linked to brain ischemia.