NUP88, CLNS1A, GTF2A2, ANXA1, SOD1, PRDX1, and CD3D were negatively correlated with M0-type macrophages in AD patients (r < −0.3, P < 0.001), while GTF2H5, SOD1, and LDHB were negatively correlated with M0-type macrophages in the IS patients (r < −0.3, P < 0.001). The gene discussed is NUP88; the disease is Alzheimer disease.