SNCA and Parkinson disease: NatB acetylates essential proteins at the N-terminus such as tropomyosin, actin, and alpha-synuclein (αS); is required for stability of the actin cytoskeleton; is vital for cell-cycle progression (Starheim et al., 2008), cell proliferation (Ametzazurra et al., 2008); and is implicated in diseases such as hepatocellular carcinoma and Parkinson’s disease (PD) (Polevoda and Sherman, 2003; Ametzazurra et al., 2008; Halliday et al., 2011; Neri et al., 2017).