RGS4 and inborn error of immunity: Three hub DE-FRGs (PRDX6, GABARAPL1, and TSC22D3) were significantly upregulated in cluster A compared with cluster B. ZFP36 and RGS4 were significantly upregulated in cluster B. GSVA enrichment revealed that gene cluster A was mainly enriched in inositol phosphate metabolism and regulation of autophagy biological functions, while gene cluster B was related to the biological functions or pathways such as glycan biosynthesis, glycosaminoglycan biosynthesis, chondroitin sulfate, P53 signaling pathway, and primary immunodeficiency (Figure S3(e)).