RHOA and Hyperglycemia: Sharma et al. findings suggest that kaempferol inhibits hyperglycemia-induced activation of RhoA and decreases oxidative stress, proinflammatory cytokines (TNF-α and IL-1β), and fibrosis (TGF-β1 expression and extracellular matrix protein expression) in NRK-52E and RPTEC cells [63].