Then, the Wilcoxon test was used to compare the expression differences of 7 hub DE-FRGs in DKD samples and CON samples, and the results showed that DUSP1, PRDX6, PEBP1, ZFP36, TSC22D3, and GABARAPL1 were significantly reduced in DKD samples (p < 0.05). This evidence concerns the gene DUSP1 and diabetic kidney disease.