MAPK14 and hepatocellular carcinoma: To explore whether activation of the p38 pathway regulates ferroptosis in HCC cells, we used C11-BODIPY staining to examine the accumulation of lipid reactive oxygen species (lipid-ROS) and found that anisomycin significantly increased intracellular lipid-ROS, while SB203580 coincubation almost completely rescued the accumulation of lipid-ROS (Figure 1(d)).