Therefore, the expression levels of the cell stemness-related proteins (c-Myc, CD133, Nanog, CD24, and EpCAM) and the apoptosis-related proteins (cleaved caspase-3, Bcl-2, and Bax) were also analyzed in HCC cells during anisomycin treatment, and the changes in protein expression were consistent with the phenotypic changes above (Supplementary Figures 2A-D). Here, PROM1 is linked to hepatocellular carcinoma.