TNF and systemic inflammatory response syndrome: Sustained hepatocyte injury is followed by the release of pro-inflammatory inflammatory factors (IL-1β, IL-6, IL-8, TNF-α, IFN-γ, IFN-α, IL-17) and anti-inflammatory inflammatory factors (IL-10), resulting in persistent injury, immune paralysis, systemic inflammatory response syndrome and sepsis, etc., eventually leading to organ failure (17).