The concentrations of microbicidal peptide human neutrophil α-defensins, dermcidin and Th2-related chemokines CCL17, macrophage-derived chemokine (MDC)/CCL22, and cutaneous T-cell-attracting chemokine (CTACK)/CCL27 in patients with AD were significantly increased, among them CCL27 and CCL22 were positively correlated with SCORAD, meanwhile, CTACK was positively correlated with pruritus in patients with AD (57). Here, DCD is linked to Alzheimer disease.