Genes expression of cellular markers expressed significantly increased, including T cells (CD3), AD-associated dendritic cells (Fc ε RI, and OX40L) and inflammatory markers (MMP12), innate immunity (IL-8 and IL-6), Th2 (IL-4, IL-13, and chemokines CCL17/TARC, CCL26/eotaxin-3), Th17/Th22 (IL-19, IL-22, IL-17F, IL-26, IL-36G, and S100As) and T-regs (FOXP3), which were positively correlated with Total Sign Score and Investigator’s Global Assessment (IGA) Score (65, 66). The gene discussed is IL4; the disease is Alzheimer disease.