To determine whether m6A modification impacts the pathogenesis and development of pSS, we detected the mRNA levels of METTL3, WTAP, RBM15, FTO, ALKBH5, YTHDF1, YTHDF2, YTHDF3, YTHDC1, YTHDC2, ISG15, and USP18 in peripheral blood from patients with pSS, patients with non-SS sicca, and healthy controls (HCs). Here, METTL3 is linked to peeling skin syndrome.