HLA-C and cancer: Genomic instability, as proven through the microsatellite instability (MSI) or tumour mutational burden (TMB) status, presents a mechanism for developing precise antigenicity for a malignant tumour via means of imparting the host's immune system with something overt and foreign (non-self) to lock onto a cancer-associated antigen to the major histocompatibility complex (MHC) [10].