It was shown to be mediated by the interaction of Peptostreptoccus anaerobius and toll-like receptor-2/4, which induces the formation of reactive oxygen species (ROS), and regulates sterol regulatory element-binding protein 2 (SREBP2), which increases fat formation, activates pro-oncogenic factors and pathways that predispose to colorectal cancer [19]. The gene discussed is SREBF2; the disease is colorectal cancer.