OSLER-1: Open-Label Study of Long-Term Evaluation against LDL Cholesterol 1; ACC/AHA: American College of Cardiology/American Heart Association; PCSK9: proprotein convertase subtilisin/kexin type 9; FH: familial hypercholesterolemia; LDL-C: low-density lipoprotein cholesterol; EBBINGHAUS: Evaluating PCSK9 Binding Antibody Influence on Cognitive Health in High Cardiovascular Risk Subjects; ODYSSEY LONG TERM: Long-term Safety and Tolerability of Alirocumab in High Cardiovascular Risk Patients with Hypercholesterolemia Not Adequately Controlled with Their Lipid Modifying Therapy. This evidence concerns the gene PCSK9 and familial hypercholesterolemia.