PRKN and type 2 diabetes mellitus: Additionally, an increase in the mRNA and protein expression of MFN2 and several mitophagy-related proteins (NIX, PINK1, and PARKIN) has been reported in prediabetic subjects, whereas patients with T2DM showed a decreased expression of these proteins (64), demonstrating the important role of mitophagy and mitochondrial dynamic in the pathogenesis of T2DM.