INS and polycystic ovary syndrome: MiR-133a and miR-133b participate in the expression of the GLUT4 protein through the Kruppel-like transcription factor 15 (KLF15) and reduce insulin-stimulated glucose utilization to control IR, whereas, miR-143 is involved in GLUT4 expression (80, 97), GULT4 may be a target of miRNAs for IR treatment in PCOS patients.