SP7 and type 2 diabetes mellitus: Table 3 shows the values of biomechanical parameters of femur in T2DM group and C group. The mechanical parameters (maximum load, fracture load, yield stress, and elastic modulus) were also reduced in T2DM mice (all p < 0.05) (Figures 5A-F). HFD caused a decrease in the expression of the OSX and ALP genes in all six groups (all p < 0.05) (Figures 6A, C).