However, NBR1 were also expressed in the cystic wall of renal glomeruli, indicating that its expression may be affected no matter whether the ball or the gym is injured, so it is more likely to show the difference of blood and urine concentration expression in different stages.Therefore, a significant downward trend of this protein was found in the verification test of blood and urine, which further indicated that NBR1 may be an important autophagy protein associated with the development and progression of DKD. The gene discussed is NBR1; the disease is diabetic kidney disease.