We would like to recommend that the pseudocapsules be removed as aggressively as possible in order to reduce tumor remnants and recurrences, and improve endocrine remission rate, especially for some functional adenomas such as ACTH and GH-secreting adenomas, as well as the high-risk PitNETs as described in the 2017 WHO classification of endocrine organs tumors, including sparsely granulated growth hormone adenomas, male lactation for steroid adenomas, Crooke cell adenomas, and corticotropin-silencing adenomas (41). This evidence concerns the gene POMC and adenoma.