Currently, GLP-1R agonists used in the treatment of AD models include (Val8)GLP-1, GLP-1(9-36)amide, GLP-1(7-36)amide, CJC-1131, Geniposide, Exendin(5-39), Exendin-4, NLY01 (engineered exendin-4), liraglutide, Lixisenatide, Dulaglutide, Exenatide, GLP-1, dual GLP-1/GIP receptor agonist (DA-JC4, DA-JC1, DA5-CH, DA-CH3), GLP-1/GIP/Gcg receptor triagonist (triagonist, TA), dual GLP-1 and Gcg receptor agonist (oxyntomodulin) (144, 147, 148, 150, 171, 180, 186, 189, 194, 218, 219, 228, 235, 237, 238, 241, 242). The gene discussed is GIP; the disease is Alzheimer disease.