ICAM1 and ischemia: CCL-2 infusion of the femoral artery of rabbits following hindlimb ischemia increased monocyte accumulation in the vessel wall (26); a finding that was inhibited with ICAM-1 monoclonal antibody treatment (27), suggesting that monocyte adhesion to the endothelium in ischemia involves CCL-2 and ICAM-1.