PCLO and neoplasm: We found that PCLO (piccolo presynaptic cytomatrix protein), PIM1, CD79B and MYD88 (genes involved in the NF-κB signaling pathway), LRP1B and TP53 (tumor suppressive genes), as well as KMT2D and HIST1H1E (histone modifying genes) were the most commonly mutated genes in the 169 newly diagnosed DLBCL patients.