According to literature, genes related to histone methylation or acetylation (EZH2, EP300, CREBBP and KMT2D) and the PI3K/AKT and JAK/STAT pathways are commonly mutated in the GCB subtype of DLBCL patients, while genes related to the B-cell receptor and NF-κB signaling pathways, such as MYD88, CD79A/B, CARD11, PIM1 and TNFAIP3, are commonly mutated in the ABC subtype (20). This evidence concerns the gene EP300 and diffuse large B-cell lymphoma.