Using differentially expressed gene analysis, univariate Cox regression analysis, Lasso regression, and multivariate Cox regression analysis, nine characteristic genes that were highly correlated with the prognosis of CRC patients, namely carnitine palmitoyltransferase 2 (CPT2), PPARG Coactivator 1 Alpha (PPARGC1A), Ladybird Homeobox 2 (LBX2), pannexin 2 (PANX2), LOC339674, G protein-coupled receptor 156 (GPR156), PTPRF interacting protein alpha 4 (PPFIA4), LDL receptor related protein 2 (LRP2), and mannose binding lectin 1, pseudogene (MBL1P), were identified for developing the RS signature. This evidence concerns the gene GPR156 and colorectal carcinoma.