Therefore, the immanent reason may be that the high neutrophil count is a symbol of an adequate environment for tumor progression, which has been shown to promote tumor growth and metastasis by secreting chemokines, vascular endothelial growth factor, and matrix metalloproteinase-9, which are involved in the development of local inflammation and angiogenesis (21–23). The gene discussed is MMP9; the disease is neoplasm.