Compared to non-tumor tissues- Enhanced interactions between non-immune cells (including MKI67+ goblet cells, DEFA5+DEFA6+ metaplastic paneth cells, colonocytes, and fibroblasts) and immune cells (including B cells, T cells and myeloid cells) in tumor tissues.- Altered interaction pathways between B cells and T cells. Here, DEFA5 is linked to neoplasm.