Consistently, our previous study showed that the nuclear ZHX2 is reduced in human HCC tissues compared with adjacent nontumor tissues and nuclear ZHX2 represses HCC cell growth by inhibition of cell cycle genes (Cyclin A and Cyclin E), demonstrating for the first time the tumor suppressor activity of ZHX2 in HCC (6). The gene discussed is ZHX2; the disease is neoplasm.