Integrative bioinformatics analyses reveal that a miRNA-related SNP (rs3802266-G), which creates a stronger binding site for miR-181-a-2-3p in 3’UTR of ZHX2 mRNA and consequently reduces ZHX2 expression, was significantly associated with increased risk of pancreatic cancer (56). The gene discussed is ZHX2; the disease is familial pancreatic carcinoma.