IGFBP5 and ovarian cancer: In ovarian cancer, a study investigating mRNA and protein levels of IGFBP family members in normal and cancerous tissues found that IGFBP5 was decreased in cancerous tissue relative to normal ovarian tissue, however the same study reported a strong association between increased expression of IGFBP5 and decreased progression-free survival and overall survival in all subtypes of ovarian cancer (62).