IGFBP5 has been identified as a hub gene in osteosarcoma along with origin recognition complex subunit 6 (ORC6), minichromosome maintenance 10 replication initiation factor (MCM10), MET proto-oncogene, receptor tyrosine kinase (MET) and centromere protein F (CENPF) (102). This evidence concerns the gene ORC6 and osteosarcoma.