The same study demonstrated that intratumoral injection of IGFBP5 into subcutaneous xenografts with SKOV3 ovarian cancer cells prevented further tumor growth and inhibited vascularization as measured with CD31 staining (74), setting a solid framework for future studies investigating the role of IGFBP5 as a potential tumor suppressor. This evidence concerns the gene IGFBP5 and ovarian cancer.