We further explored the correlation between MCMs and clinical characteristics of glioma and uncovered that up-regulated MCM2-MCM8 and MCM10 were significantly associated with the higher tumor stage, IDH mutation status, 1p/19q chromosome co-deletion, histological type, and primary therapy outcome based on the TCGA dataset (Figures 3, 4, 5A; Supplementary Figure 1), this result was verified by CGGA and Rembrandt datasets (Supplementary Figures 2–5). The gene discussed is IDH1; the disease is central nervous system cancer.