CA19-9 (HR=2.928[1.401-21.354], P=0.048), CEA (HR=9.404[2.240-39.196], P=0.031) and lymphatic metastasis (HR=1.822[1.203-3.321], P=0.023) were still markedly related to OS, while postoperative adjuvant chemotherapy had no significant influence on OS (P=0.343) (Table 3). This evidence concerns the gene CEACAM5 and Lymphatic Metastasis.