RBP4 and acute myeloid leukemia: Some limitations of this study also exist, (a) Some functional experiments were needed to further illustrate the underlying molecular mechanisms to predict the role of the cellular pyroptosis-related differential RBP genes in AML; (b) The prognostic model should be validated by more datasets and clinical samples; (c) This study only used bioinformatics methods to conduct multiple analyses based on retrospective data from the public databases, confirmatory experiments in vivo and in vitro will be required subsequently.