Since considering that m6A modification can promote protein expression by stabilizing mRNAs (36, 39), we further screened highly expressed and hypermethylated molecules which regulated by METTL3, and the AVEN, DAZAP2, DNAJB1, EPB41L3, and OPLAH molecules were selected for further analysis The results showed that the expression levels of AVEN and DAZAP2 were significantly correlated with the clinicopathological grade and stage of GC patients. The gene discussed is METTL3; the disease is gastric cancer.