METTL3 and neoplasm: Finally, AVEN and DNAJB1 (19, 20), which have DNA damage and tumor formation roles in tumors were selected to verify their protein expression levels in BGC-823 control and METTL3 overexpression cell lines, and the results showed that the AVEN and DNAJB1 level were significantly upregulated by METTL3 expression (Figure 6H).