Similar results are as follows, a study showed that circ-KIAA1244 in GC tissues, plasma and cells was significantly lower compared with normal controls by analysing the circRNA expression profiles in plasma samples from 10 GC patients with different TNM stages and 5 healthy people, and further clinical data analysis showed that the low expression of circ-KIAA1244 in plasma was negatively correlated with TNM stage, lymph node metastasis and overall survival time in GC patients (61). The gene discussed is ARFGEF3; the disease is metastatic malignant neoplasm in the lymph nodes.