TGFB1 and systemic lupus erythematosus: However, the secretion of transforming growth factor β (TGF-β1) and IL-6 and IL-7 mRNA in SLE BM-MSCs were decreased, which may cause hematopoietic damage and immune imbalance.[37] SLE patients’ BM-MSCs were defective in inhibiting T cell and B cell proliferation, as well as plasma cell terminal differentiation.[39,40] It can be hypothesized that such defects lead to immune and hematopoietic dysregulation, resulting in clinical disease.