It has been put forward earlier that hypothyroidism increases the risk of atherogenesis and coronary artery diseases through various mechanisms like a decreased expression of Ca2+-ATPase in sarcoplasmic reticulum or disinhibition of ATPase by increased expression of phospholamban or modulation of the renin-angiotensin-aldosterone axis [22]. This evidence concerns the gene DNAH8 and coronary artery disorder.