IL17F and colitis: To study the role of mTOR in the enhanced expression of IL-17A, IL-17F, and IFN-γ in TSC1cKO macrophages and the more severe symptoms of acute colitis in TSC1cKO mice, we produced mice with mTOR deletion (LysMCremTORloxp/loxp or mTORcKO) or with TSC1 and mTOR double deletion (LysMCreTSC1loxp/loxp/mTORloxp/loxp; herein referred to as TSC1/mTORcKO) in myeloid cells.